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☆ More people need transplants than there are organ donors. Pigs might offer a solution
▼ + stars: | 2024-01-30 | by ( Jen Christensen | ) edition.cnn.com time to read: +23 min

The need for more transplant organs is immense and growing. Researchers have transplanted genetically modified pig kidneys and hearts into people who were brain-dead to test whether they work in humans. Although Larry Faucette was too sick for a human heart transplant, University of Maryland doctors said he seemed physically strong enough for a genetically modified pig heart. It was more than a decade after the first heart transplant but long before such procedures became relatively routine. “We learned that the pig heart is an adequate substitute for a human heart.

Persons: Lawrence Faucette, Ann, he’d, ” Ann, Larry Faucette, Ann Faucette Ann, Larry, didn’t, ”, Robert Montgomery, “, Shelby Lum, ” Montgomery, Xenotransplantation, Art Caplan, Caplan, Babe ”, ” Caplan, They’re, eGenesis, people’s, Dr, Mike Curtis, Sanjay Gupta, ” Curtis, hasn’t, Julie O’Hara, Jim Parsons, Jayme Locke, couldn’t, Locke, Parsons, NYU —, Montgomery —, O’Hara, ” Locke, David Bennett Sr, Mary, David Jr, Bartley Griffith, Bennett, they’ve, Muhammad M, Mohiuddin, Larry Faucette’s, David Bennett’s, ” Griffith, xenotransplantation Ann Faucette, Wilbur, White’s, Ann Faucette, NYU ethicist Caplan, they’re, NYU’s Montgomery, UAB’s Locke, Steve Wood, ’ Curtis, “ I’m, it’s, ” O’Hara, Bennett’s, Larry Faucette —, ” Bennett’s, Faucette, who’d, Griffith, would’ve, Kate, Lucy, Nadia Kounang Organizations: CNN, Food and Drug Administration, University of Maryland, FDA, National Institute of Allergy, NYU Langone Transplant Institute, NYU Langone's Transplant, NYU Grossman School, Medicine’s Department of Population Health, “ Disney, University of Alabama, Transplant Institute, Parsons Family, Birmingham, NYU, University of Maryland School of Medicine, Doctors, University of Maryland Medical Center, Uno, UAB, CNN Health, NFL Locations: Frederick , Maryland, United States, Montgomery, “, Midwest, Yucatan, Maryland

It marked the longest a genetically modified pig kidney has ever functioned inside a human, albeit a deceased one. “Two months is a lot to have a pig kidney in this good a condition. Political Cartoons View All 1160 ImagesSo-called xenotransplantation attempts have failed for decades — the human immune system immediately destroyed foreign animal tissue. Montgomery gambled that maintaining Miller's body on a ventilator for two months to see how the pig kidney worked could answer some of those questions. She recently got a card from a stranger in California who's awaiting a kidney transplant, thanking her for helping to move forward desperately needed research.

Persons: gurney, Maurice “ Mo ” Miller, “, Dr, Robert Montgomery, Montgomery, ”, Mary Miller, Duffy, Miller, ” Miller, Sue Duffy, Montgomery’s, immunologist Massimo Mangiola, Jeffrey Stern, Karen Maschke, Mangiola Organizations: NYU Langone, Food and Drug Administration, Associated Press, University of Maryland, FDA, NYU, Hastings Center, Associated Press Health, Science Department, Howard Hughes Medical Institute’s Science, Educational Media Group, AP Locations: Newburgh , New York, California

☆ Two research teams detail advancements in transplanting pig kidneys to humans, marking key steps on path to clinical trials
▼ + stars: | 2023-08-16 | by ( Deidre Mcphillips | ) edition.cnn.com time to read: +5 min

CNN —New advancements in transplanting pig kidneys to humans, detailed by two separate research teams on Wednesday, mark key steps forward in the evolving field of xenotransplantation, the use of non-human tissues or organs to treat medical conditions in humans. Both research teams used genetically modified pig kidneys that were transplanted into recipients experiencing brain death in what is considered pre-clinical human research. Other studies have demonstrated that this can occur when pig kidneys are transplanted in non-human primates. The team has been monitoring pig kidney transplants in a brain-dead decedent – a man named Maurice Miller, known as Mo, who died of a brain tumor – for nearly two months. “Over the last 20 years, we’ve gained a lot of information about how pig kidneys work to replace the functions in primates.

Persons: ”, Jayme Locke, Locke, ” Locke, NYU Langone, Maurice Miller, Mo, Robert Montgomery, Dr, Sanjay Gupta, “ We’re, Adam Griesemer, we’ve, ’ –, we’re Organizations: CNN, University of Alabama, Birmingham Heersink School of Medicine, New York University, Health, Comprehensive Transplant Institute, ”, UAB, NYU, NYU Langone Transplant Institute, CNN Health, Liver Transplant, FDA, US Department of Health, Human, Transplantation Network

☆ About 17 Americans die waiting for transplants each day. Scientists are trying to make more organs in 5 creative ways.
▼ + stars: | 2022-10-18 | by ( Morgan Mcfall-Johnsen | ) www.businessinsider.com time to read: +11 min

Courtesy of Leilani GrahamIf pig organs turn out to be just as effective as human organs, she added, "That is more appealing to me than using marginal donors." If the technique works for human organs in the future, it could allow clinicians to preserve many more organs for donation after death. Changing organs' blood typeEnzymes are delivered to a lung inside a perfusion machine at Dr. Marcelo Cypel’s lab. Growing synthetic organs from stem cellsResearcher Stormy Chamberlain holds a tray of stem cells at the University of Connecticut's Stem Cell Institute. Hanna started a company called Renewal Bio to pursue the possibility of turning stem cells into organs for transplants.

☆ 5 cutting-edge medical experiments could expand our organ supply, from gene-edited pigs to artificial embryos
▼ + stars: | 2022-09-24 | by ( Morgan Mcfall-Johnsen | ) www.businessinsider.com time to read: +10 min

Courtesy of Leilani GrahamIf pig organs turn out to be just as effective as human organs, she added, "That is more appealing to me than using marginal donors." While much of the shortage is driven by imperfect logistics and bureaucracy rather than supply, cutting-edge research could make organs — human, pig, or synthetic — more accessible in Graham's lifetime. If the technique works for human organs in the future, it could allow clinicians to preserve many more organs for donation after death. Changing organs' blood typeEnzymes are delivered to a lung inside a perfusion machine at Dr. Marcelo Cypel’s lab. Growing synthetic organs from stem cellsResearcher Stormy Chamberlain holds a tray of stem cells at the University of Connecticut's Stem Cell Institute.

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